MEDomics Lab · UCSF Radiation Oncology

Quantitative models of disease and toxicity for radiation oncology.

We pool imaging and clinical data across institutions to measure where disease arises and how the brain responds to radiation, and test whether those measurements can make treatment safer. The lab leads the MEDomics Consortium and the AAPM Working Group SCALE.

NIHSupported by the National Cancer Institute · R01CA292043NIH RePORTER ↗
Where brain metastases occur · population frequency map of 13,926 lesions from 4 institutions, current atlas update.

Mission

To facilitate the development and clinical translation of data-driven research in cancer care.

  • Imaging standards: DICOM, IBSI
  • Clinical language processing
  • Deep learning for segmentation and prediction
  • Ontologies and distributed learning across institutions

Brain metastasis atlas

One map from four institutions

Patients
3,290
Lesions
13,926
Institutions
4
Reference atlases
4

Current update of the atlas, in three planes and in 3D, by primary cancer and by anatomical, functional and vascular region.

Open the Brain AtlasContributing institutions

Research

Three areas of work

NIH/NCI R01 · ActiveBrain MetastasesWhere metastases arise, and whole brain radiotherapy that spares the regions they rarely reach.Open feeding arteries draining vein nidus TARGET AVM · PlanningAVM RadiosurgeryAdaptive radiosurgery for large arteriovenous malformations, guided by 4D angiography and flow MRI.OpenMEDomics platform · EstablishedClinical Data ScienceHospital records, imaging and text organized so models can be built and validated across institutions.Open

Video

The MEDomics Consortium

How MEDomics turns the records, imaging and text that hospitals already collect into data that models can learn from, across institutions.

Clinical Data Science

News and updates

Latest

  1. 2025-08Brain MetastasesWBRT PROTECT (R01CA292043) funded by the National Cancer Institute.
  2. 2025-08Clinical Data ScienceGlioblastoma recurrence prediction for target definition published in npj Digital Medicine.
  3. 2025-07Clinical Data ScienceOncology language model predicting cancer progression published in npj Digital Medicine.
  4. 2025-05Brain MetastasesMulti-institutional brain metastasis atlas published in Nature Communications.
  5. 2025AAPM SCALEOlivier Morin appointed chair of the AAPM Working Group SCALE.
All news

Publications

Featured papers

First page of the articleNature Communications · 2025Multi-institutional atlas of brain metastases First page of the articleNature Cancer · 2021AI framework for continuous pan-cancer prognostication
All 75 articles

AAPM Working Group SCALE

Collaborative data science in radiation therapy

ProjectsThe working group's projects, one card each.Open SCALE ConsoleThe application sites run to prepare and submit data.Open Contribute a siteShare de-identified data, or run the pipeline locally.Open

People

Join the lab

For prospective students, postdocs and visiting scholars.

Join the lab

Partners

Collaborate with us

Joint studies, data contributions and access to our tools.

Contact the lab